No, TRU NIAGEN® does not need to be refrigerated. That’s because Tru Niagen® is formulated with a crystalline form of nicotinamide riboside chloride. This crystalline form is shelf-stable when stored under the recommended conditions listed on the Tru Niagen® bottle. ChromaDex specifically formulates our products to enhance the overall stability and quality. We also conduct our own internal testing and development to ensure the bottle contains what is stated on the Tru Niagen® label.